Article
Unsupervised Analysis of Array Comparative Genomic Hybridization Data from Early-Onset Colorectal Cancer Reveals Equivalence with Molecular Classification and Phenotypes.
Neoplasia (New York, N.Y.) - 1 Jan 2017
Arriba María, García Juan L, Rueda Daniel, Pérez Jessica, Brandariz Lorena, Nutu Oana A, Alonso Laura, Rodríguez Yolanda, Urioste Miguel, González-Sarmiento Rogelio, Perea José
Abstract excerpt
AIM: To investigate whether chromosomal instability (CIN) is associated with tumor phenotypes and/or with global genomic status based on MSI (microsatellite instability) and CIMP (CpG island methylator phenotype) in early-onset colorectal cancer (EOCRC). METHODS: Taking as a starting point our previous work in which tumors from 60 EOCRC cases (≤45 years at the time of diagnosis) were analyzed by array comparative...
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