Article

Novel Epigenetic 12-gene Signature Predictive of Poor Prognosis and MSI-like Phenotype in Human Metastatic Colorectal Carcinomas

2020-09-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Epigenetic remodeling is responsible for tumor progression and drug resistance in human colorectal carcinoma (CRC). A subgroup of human CRCs exhibits the CIMP status, with extensive hypermethylation events in promoter regions of several genes, even though the prognostic significance of CIMP is controversial. This study addressed the hypothesis that DNA methylati...

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Literature Corpus work: ab4ae19c-49e7-5252-aeda-2de1bbfbe7a3
DOI: 10.21203/rs.3.rs-74746/v1

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