Article
Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.
Forensic science international - 1 Aug 2018
Matsusue Aya, Ikeda Tomoya, Tani Naoto, Waters Brian, Hara Kenji, Kashiwagi Masayuki, Takayama Mio, Ikematsu Natsuki, Kubo Shin-Ichi, Ishikawa Takaki
Abstract excerpt
Methamphetamine (MA) is an illicit stimulant that affects the central nervous system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism. Numerous allelic variants confer substantial variation in CYP2D6 activity among individuals. In the present study, we examined the frequencies of CYP2D6 alleles, including CYP2D6*1, *2, *4, *5, *10, *14A, *14B, *18, and *36, and multiplication, in 82 forensic...
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