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Article

Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder.

Neuroscience letters - 23 Mar 2021

Deji Cuola, Li Yunxiao, Chen Yuanyuan, Lai Jianghua, Wei Shuguang

Abstract excerpt

Heroin use disorder is a chronic relapsing brain disease containing multiple phenotypes. These phenotypes vary among heroin users and might be influenced by genetic factors. Single-nucleotide polymorphisms (SNPs) of catechol-O-methyltransferase (COMT) and alpha-1-adrenergic receptor (ADRA1A) genes are associated with heroin use disorder. However, it has not been clarified which phenotypes of heroin use disorder...

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PMID: 33577997
DOI: 10.1016/j.neulet.2021.135677

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