Article
Novel interacting proteins identified by tandem affinity purification coupled to nano LC-MS/MS interact with ribosomal S6 protein kinase 4 (RSK4) and its variant protein (RSK4m).
International journal of biological macromolecules - 1 Mar 2017
Liu Riqiang, Liu Tianhua, Wei Wei, Guo Kun, Yang Ning, Tian Siqi, Zhu Jia, Liu Yinkun, Zhou Wenting, Yang Huawei
Abstract excerpt
Ribosomal S6 protein kinase 4 (RSK4) is an important novel tumor suppressor that inhibits breast cancer cell growth and induces senescence. However, RSK4m, which is a variant of RSK4 resulting from alternative splicing, may play distinct roles in some aspects. Knowledge about the mechanisms of RSK4 or RSK4m activity has been lacking. Analysis of the RSK4 and RSK4m interactome could provide insight into their...
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