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RSK1 and RSK2 serine/threonine kinases regulate different transcription programs in cancer

4 Jan 2023

Abstract excerpt

The 90 kDa ribosomal S6 kinases (RSKs) are serine threonine kinases comprising four isoforms. The isoforms can have overlapping functions in regulation of migration, invasion, proliferation, survival, and transcription in various cancer types. However, isoform specific differences in RSK1 versus RSK2 functions in gene regulation are not yet defined. Here, we delineate ribosomal S6 kinases isoform-specific...

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PMID: 36684450
DOI: 10.3389/fcell.2022.1015665

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