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A STAT3 protein complex required for mitochondrial mRNA stability and cancer

1 Sept 2023

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its activity as a transcription factor until the discovery of a mitochondrial pool of STAT3, which is necessary for normal tissue function and tumorigenesis. However, the mechanism of...

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PMID: 37703176
DOI: 10.1016/j.celrep.2023.113033

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