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Pharmacogenomic Profiling of ADME Gene Variants: Current Challenges and Validation Perspectives

18 Dec 2018

Abstract excerpt

In the past decades, many efforts have been made to individualize medical treatments, taking into account molecular profiles and the individual genetic background. The development of molecularly targeted drugs and immunotherapy have revolutionized medical treatments but the inter-patient variability in the anti-tumor drug pharmacokinetics (PK) and pharmacodynamics can be explained, at least in part, by genetic...

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PMID: 30567415
DOI: 10.3390/ht7040040

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