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Article

Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2016

Calderaro Julien, Nault Jean C, Balabaud Charles, Couchy Gabrielle, Saint-Paul Marie-Christine, Azoulay Daniel, Mehdaoui Dalila, Luciani Alain, Zafrani Elie S, Bioulac-Sage Paulette, Zucman-Rossi Jessica

Abstract excerpt

Hepatocellular adenoma is considered to occur exclusively in non-fibrotic livers. It is a heterogeneous entity and a molecular classification is now widely accepted. The most frequent hepatocellular adenoma subtype, namely inflammatory adenoma, harbor somatic activating mutations of genes involved in the interleukin-6 pathway that lead to high C-reactive protein and serum amyloid A expression. The aim of our...

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Share to Adenoma, Liver Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokine Receptor gp130

Share to End Stage Liver Disease

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Hepatocyte Nuclear Factor 1-alpha

Share to STAT3 Transcription Factor

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Source

Identifiers

PMID: 26516697
DOI: 10.1038/modpathol.2015.119

Genes

GNAS
STAT3
CTNNB1
TERT

Provenance

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