Article
Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2.
Scientific reports - 16 Dec 2016
Ohno Shouichi, Ikeda Jun-Ichiro, Naito Yoko, Okuzaki Daisuke, Sasakura Towa, Fukushima Kohshiro, Nishikawa Yukihiro, Ota Kaori, Kato Yorika, Wang Mian, Torigata Kosuke, Kasama Takashi, Uchihashi Toshihiro, Miura Daisaku, Yabuta Norikazu, Morii Eiichi, Nojima Hiroshi
Abstract excerpt
Cyclin G1 (CycG1) and Cyclin G2 (CycG2) play similar roles during the DNA damage response (DDR), but their detailed roles remain elusive. To investigate their distinct roles, we generated knockout mice deficient in CycG1 (G1KO) or CycG2 (G2KO), as well as double knockout mice (DKO) deficient in both proteins. All knockouts developed normally and were fertile. Generation of mouse embryonic fibroblasts (MEFs) from...
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