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Article

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations.

Journal of virology - 1 Mar 2017

Renzette Nicholas, Pfeifer Susanne P, Matuszewski Sebastian, Kowalik Timothy F, Jensen Jeffrey D

Abstract excerpt

Intrahost and interhost assessments of viral diversity are often treated as measures of separate and distinct evolutionary processes, with numerous investigations reporting seemingly incompatible results between the two. For example, in human cytomegalovirus, the nucleotide diversity estimates are 10-fold higher for interhost data, while the number of segregating (i.e., polymorphic) sites is 6-fold lower. These...

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Identifiers

PMID: 27974561
DOI: 10.1128/JVI.01976-16
PMCID: PMC5309957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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