Article
Human cytomegalovirus intrahost evolution-a new avenue for understanding and controlling herpesvirus infections.
Current opinion in virology - 1 Oct 2014
Renzette Nicholas, Gibson Laura, Jensen Jeffrey D, Kowalik Timothy F
Abstract excerpt
Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV...
Topics
- Cytomegalovirus
- Cytomegalovirus Infections
- Evolution, Molecular
- Genetic Variation
- Humans
- Spatio-Temporal Analysis
