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Article

Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.

Annals of the rheumatic diseases - 1 Jul 2017

Panoutsopoulou Kalliope, Thiagarajah Shankar, Zengini Eleni, Day-Williams Aaron G, Ramos Yolande Fm, Meessen Jennifer Mta, Huetink Kasper, Nelissen Rob Ghh, Southam Lorraine, Rayner N William, Doherty Michael, Meulenbelt Ingrid, Zeggini Eleftheria, Wilkinson J Mark

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of clinically relevant endophenotyping according to site of maximal joint space narrowing (maxJSN) and bone remodelling response on GWAS signal detection in hip OA....

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Share to Atrophy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage, Articular

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Share to Osteoarthritis, Hip

Source

Open in PubMed Open full text

Identifiers

PMID: 27974301
DOI: 10.1136/annrheumdis-2016-210373
PMCID: PMC5530347

Genes

GADL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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