Article
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.
Osteoarthritis and cartilage - 1 Mar 2011
Kerkhof H J M, Meulenbelt I, Akune T, Arden N K, Aromaa A, Bierma-Zeinstra S M A, Carr A, Cooper C, Dai J, Doherty M, Doherty S A, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart D J, Hauksson V B, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala U M, Lane N E, Leino-Arjas P, Lohmander L S, Luyten F P, Malizos K N, Nakajima M, Nevitt M C, Pols H A P, Rivadeneira F, Shi D, Slagboom E, Spector T D, Stefansson K, Sudo A, Tamm A, Tamm A E, Tsezou A, Uchida A, Uitterlinden A G, Wilkinson J M, Yoshimura N, Valdes A M, van Meurs J B J
Abstract excerpt
OBJECTIVE: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. METHODS: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating...
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