Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study.

doi:10.1371/journal.pone.0159024

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Article

Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study.

PloS one - 1 Jan 2016

Reynard Louise N, Ratnayake Madhushika, Santibanez-Koref Mauro, Loughlin John

Abstract excerpt

The single nucleotide polymorphism (SNP) rs835487 is associated with hip osteoarthritis (OA) at the genome-wide significance level and is located within CHST11, which codes for carbohydrate sulfotransferase 11. This enzyme post-translationally modifies proteoglycan prior to its deposition in the cartilage extracellular matrix. Using bioinformatics and experimental analyses, our aims were to characterise the...

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Identifiers

PMID: 27391021
DOI: 10.1371/journal.pone.0159024
PMCID: PMC4938163

Genes

CHST11
SUB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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