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Article

The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.

PloS one - 1 Jan 2016

Bhat Neha, Park Jeehye, Zoghbi Huda Y, Arthur J Simon C, Zaret Kenneth S

Abstract excerpt

Type I diabetes is caused by loss of insulin-secreting beta cells. To identify novel, pharmacologically-targetable histone-modifying proteins that enhance beta cell production from pancreatic progenitors, we performed a screen for histone modifications induced by signal transduction pathways at key pancreatic genes. The screen led us to investigate the temporal dynamics of ser-28 phosphorylated histone H3...

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Identifiers

PMID: 27973548
DOI: 10.1371/journal.pone.0166703
PMCID: PMC5156359

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