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Article

Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation

23 Dec 2014

Abstract excerpt

UNLABELLED: The tumor suppressor gene MEN1 is frequently mutated in sporadic pancreatic neuroendocrine tumors (PanNET) and is responsible for the familial multiple endocrine neoplasia type 1 (MEN-1) cancer syndrome. Menin, the protein product of MEN1, associates with the histone methyltransferases (HMT) MLL1 (KMT2A) and MLL4 (KMT2B) to form menin-HMT complexes in both human and mouse model systems. To elucidate...

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PMID: 25537453
DOI: 10.1158/1541-7786.mcr-14-0457

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Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor FormationPMID 25537453Read ↗

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