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Directing cell differentiation with small-molecule histone deacetylase inhibitors: The example of promoting pancreatic endocrine cells

15 Feb 2009

Abstract excerpt

Genes in the mammalian genome contain information necessary to build an organism during development. Epigenetic processes add a further degree of complexity. These mechanisms of temporal and spatial control of gene activity during the development of complex organisms modulate gene expression patterns without modifying the DNA sequence. Post-translational modifications of histones such as acetylation bestow the...

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Share to Epigenetics and DNA Methylation
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PMID: 19197155
DOI: 10.4161/cc.8.4.7610

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