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Article

One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus.

Diabetes & metabolism journal - 1 Mar 2024

Zhu Jie, Saikia Gunjana, Zhang Xiaotao, Shen Xiaoxi, Kahe Ka

Abstract excerpt

Diabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance. HHcy can result from low status of one-carbon metabolism (OCM) nutrients (e.g., folate, choline, betaine, vitamin B6, B12), which work together to degrade homocysteine by methylation....

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Identifiers

PMID: 38468500
DOI: 10.4093/dmj.2023.0272
PMCID: PMC10995489

Genes

OCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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