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Article

The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes.

Cell metabolism - 4 Jun 2013

Ezzat Shereen, Zheng Lei, Florez Jose C, Stefan Norbert, Mayr Thomas, Hliang Maw Maw, Jablonski Kathleen, Harden Maegan, Stančáková Alena, Laakso Markku, Haring Hans-Ulrich, Ullrich Axel, Asa Sylvia L

Abstract excerpt

The fibroblast growth factor receptor 4 (FGFR4)-R388 single-nucleotide polymorphism has been associated with cancer risk and prognosis. Here we show that the FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3/5 signaling. This STAT activation transcriptionally induces...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23747250
DOI: 10.1016/j.cmet.2013.05.002
PMCID: PMC4005358

Genes

FGFR4
FGF19
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23747250-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes.PMID 23747250Read ↗

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