Article
The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes.
Cell metabolism - 4 Jun 2013
Ezzat Shereen, Zheng Lei, Florez Jose C, Stefan Norbert, Mayr Thomas, Hliang Maw Maw, Jablonski Kathleen, Harden Maegan, Stančáková Alena, Laakso Markku, Haring Hans-Ulrich, Ullrich Axel, Asa Sylvia L
Abstract excerpt
The fibroblast growth factor receptor 4 (FGFR4)-R388 single-nucleotide polymorphism has been associated with cancer risk and prognosis. Here we show that the FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3/5 signaling. This STAT activation transcriptionally induces Grb14 in pancreatic endocrine cells to promote insulin secretion. Knockin mice with the FGFR4 variant allele develop...
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