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Article

Homologue engagement controls meiotic DNA break number and distribution.

Nature - 12 Jun 2014

Thacker Drew, Mohibullah Neeman, Zhu Xuan, Keeney Scott

Abstract excerpt

Meiotic recombination promotes genetic diversification as well as pairing and segregation of homologous chromosomes, but the double-strand breaks (DSBs) that initiate recombination are dangerous lesions that can cause mutation or meiotic failure. How cells control DSBs to balance between beneficial and deleterious outcomes is not well understood. Here we test the hypothesis that DSB control involves a network of...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24717437
DOI: 10.1038/nature13120
PMCID: PMC4057310

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