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Article

Roles and mechanisms of ankyrin-G in neuropsychiatric disorders

6 Jul 2022

Abstract excerpt

Ankyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD). Within neurons, ankyrin-G plays an important role in localizing proteins to the axon initial segment and nodes of Ranvier or to the dendritic shaft and spines. In...

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PMID: 35794211
DOI: 10.1038/s12276-022-00798-w

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