Article
Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Harms Klaus, Lunnan Asbjørn, Hülter Nils, Mourier Tobias, Vinner Lasse, Andam Cheryl P, Marttinen Pekka, Fridholm Helena, Hansen Anders Johannes, Hanage William P, Nielsen Kaare Magne, Willerslev Eske, Johnsen Pål Jarle
Abstract excerpt
In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by key components...
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