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Article

Modeling global changes induced by local perturbations to the HIV-1 capsid.

Journal of molecular graphics & modelling - 1 Jan 2017

Bergman Shana, Lezon Timothy R

Abstract excerpt

The HIV-1 capsid is a conical protein shell made up of hexamers and pentamers of the capsid protein. The capsid houses the viral genome and replication machinery, and its opening, or uncoating, within the host cell marks a critical step in the HIV-1 lifecycle. Binding of host factors such as TRIM5α and cyclophilin A (CypA) can alter the capsid's stability, accelerating or delaying the onset of uncoating and...

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Identifiers

PMID: 27951510
DOI: 10.1016/j.jmgm.2016.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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