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Article

Hot Spots and Their Contribution to the Self-Assembly of the Viral Capsid: In Silico Prediction and Analysis.

International journal of molecular sciences - 27 Nov 2019

Díaz-Valle Armando, Falcón-González José Marcos, Carrillo-Tripp Mauricio

Abstract excerpt

The viral capsid is a macromolecular complex formed by a defined number of self-assembled proteins, which, in many cases, are biopolymers with an identical amino acid sequence. Specific protein-protein interactions (PPI) drive the capsid self-assembly process, leading to several distinct protein interfaces. Following the PPI hot spot hypothesis, we present a conservation-based methodology to identify those...

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Source

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Identifiers

PMID: 31783519
DOI: 10.3390/ijms20235966
PMCID: PMC6928768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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