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Article

First-step mutations for adaptation at elevated temperature increase capsid stability in a virus.

PloS one - 1 Jan 2011

Lee Kuo Hao, Miller Craig R, Nagel Anna C, Wichman Holly A, Joyce Paul, Ytreberg F Marty

Abstract excerpt

The relationship between mutation, protein stability and protein function plays a central role in molecular evolution. Mutations tend to be destabilizing, including those that would confer novel functions such as host-switching or antibiotic resistance. Elevated temperature may play an important role in preadapting a protein for such novel functions by selecting for stabilizing mutations. In this study, we test...

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Source

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Identifiers

PMID: 21980515
DOI: 10.1371/journal.pone.0025640
PMCID: PMC3183071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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