Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant PIK3CA Induces EMT in a Cell Type Specific Manner.

PloS one - 1 Jan 2016

Bhagirath Divya, Zhao Xiangshan, Mirza Sameer, West William W, Band Hamid, Band Vimla

Abstract excerpt

Breast cancer is characterized into different molecular subtypes, and each subtype is characterized by differential gene expression that are associated with distinct survival outcomes in patients. PIK3CA mutations are commonly associated with most breast cancer subtypes. More recently PIK3CA mutations have been shown to induce tumor heterogeneity and are associated with activation of EGFR-signaling and reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Genes, p53

Share to Genes, ras

Share to Heterografts

Share to Neoplastic Stem Cells

Share to Phosphatidylinositol 3-Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27941987
DOI: 10.1371/journal.pone.0167064
PMCID: PMC5152840

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Mutant PIK3CA Induces EMT in a Cell Type Specific Manner.PMID 27941987Read ↗

Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes.Semantic proximity Read ↗

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.Semantic proximity Read ↗

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity.Semantic proximity Read ↗

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.Semantic proximity Read ↗

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047RSemantic proximity Read ↗

Distinct Effects of EGFR Ligands on Human Mammary Epithelial Cell DifferentiationSemantic proximity Read ↗

Oncogenic <i>PIK3CA</i> promotes cellular stemness in an allele dose-dependent mannerSemantic proximity Read ↗

Oncogenic PI3Kα promotes multipotency in breast epithelial cells.Semantic proximity Read ↗

Specific Features of Epithelial-Mesenchymal Transition Induced by Driver Mutations in the PI3K/AKT Signaling Pathway in Breast Epithelial Cells.Semantic proximity Read ↗

Single Copies of Mutant KRAS and Mutant PIK3CA Cooperate in Immortalized Human Epithelial Cells to Induce Tumor FormationSemantic proximity Read ↗

Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.