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Article

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity.

Breast cancer research and treatment - 1 Apr 2017

Croessmann Sarah, Wong Hong Yuen, Zabransky Daniel J, Chu David, Rosen D Marc, Cidado Justin, Cochran Rory L, Dalton W Brian, Erlanger Bracha, Cravero Karen, Button Berry, Kyker-Snowman Kelly, Hurley Paula J, Lauring Josh, Park Ben Ho

Abstract excerpt

BACKGROUND/PURPOSE: The combined contributions of oncogenes and tumor suppressor genes toward carcinogenesis remain poorly understood. Elucidation of cancer gene cooperativity can provide new insights leading to more effective use of therapies. EXPERIMENTAL DESIGN/METHODS: We used somatic cell genome editing to introduce singly and in combination PIK3CA mutations (E545K or H1047R) with TP53 alterations (R248W or...

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Identifiers

PMID: 28190247
DOI: 10.1007/s10549-017-4147-2
PMCID: PMC6100768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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