Article
Oncogenic PI3Kα promotes multipotency in breast epithelial cells.
Science signaling - 3 Nov 2015
Okkenhaug Klaus, Roychoudhuri Rahul
Abstract excerpt
The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Now, two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to dedifferentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to increased cancer cell heterogeneity.
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