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Article

Specific Features of Epithelial-Mesenchymal Transition Induced by Driver Mutations in the PI3K/AKT Signaling Pathway in Breast Epithelial Cells.

Biochemistry. Biokhimiia - 1 Feb 2026

Dayoub Ali, Zholudeva Anna O, Fokin Artem I, Ilnitskaya Alla S, Lomakina Maria E, Gautreau Alexis M, Alexandrova Antonina Yu

Abstract excerpt

The PI3K/AKT signaling pathway is one of the most critical intracellular pathways, regulating cell proliferation, survival, and migration. Mutations in PI3K/AKT pathway components are frequently associated with progression and metastasis of malignant tumors. The initial stage of metastasis is epithelial-mesenchymal transition (EMT), during which tumor cells acquire the migratory capacity. The data on the impact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41843848
DOI: 10.1134/S0006297925603570

Genes

PIK3CA
PTEN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Specific Features of Epithelial-Mesenchymal Transition Induced by Driver Mutations in the PI3K/AKT Signaling Pathway in Breast Epithelial Cells.PMID 41843848Read ↗

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