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Article

The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure?

11 Dec 2016

Abstract excerpt

While antiretroviral therapy (ART) has improved the quality of life and increased the life span of many HIV-infected individuals, this therapeutic strategy has several limitations, including a lack of efficacy in fully restoring immune function and a requirement for life-long treatment. Two studies in this issue of the JCI use a humanized mouse model and demonstrate that type I interferon (IFN) is induced early...

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PMID: 27941242
DOI: 10.1172/jci91916

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