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Article

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2017

Turcatel Gianluca, Millette Katelyn, Thornton Matthew, Leguizamon Stephanie, Grubbs Brendan, Shi Wei, Warburton David

Abstract excerpt

The signaling cross talk between the tracheal mesenchyme and epithelium has not been researched extensively, leaving a substantial gap of knowledge in the mechanisms dictating embryonic development of the proximal airways by the adjacent mesenchyme. Recently, we reported that embryos lacking mesenchymal expression of Sox9 did not develop tracheal cartilage rings and showed aberrant differentiation of the tracheal...

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Source

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Identifiers

PMID: 27941074
DOI: 10.1152/ajplung.00127.2016
PMCID: PMC5336580

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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