Article

A tracheal aspirate-derived airway basal cell model reveals a proinflammatory epithelial defect in congenital diaphragmatic hernia

2022-11-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm and lung hypoplasia. The pathophysiology of lung defects in CDH is poorly understood. <h4>Objectives</h4> To establish a translational model of human airway epithelium in CDH for pathogenic investigation and therapeutic testing. <h4>Methods</h4> We developed a robust methodology of...

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Literature Corpus work: fb1c4de1-3601-5bb8-a24c-a0240da275a4
DOI: 10.1101/2022.11.10.515365

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