Article
Bidirectional Wnt signaling between endoderm and mesoderm confer tracheal identity in mouse and human
2019-09-05
Abstract excerpt
The periodic cartilage and smooth muscle structures in mammalian trachea are derived from tracheal mesoderm, and tracheal malformations result in serious respiratory defects in neonates. Here we show that canonical Wnt signaling in mesoderm is critical to confer trachea mesenchymal identity in human and mouse. Loss of β-catenin in fetal mouse mesoderm caused loss of Tbx4 + tracheal mesoderm and tracheal cartilage...
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Identifiers and source
- Literature Corpus work
- 2091daad-72e0-594d-8150-23be5effc105
- DOI
- 10.1101/758235