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Article

Clinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis.

European journal of drug metabolism and pharmacokinetics - 1 Sept 2026

Villalpando-Solórzano Alexandra, Ramirez-Díaz Ashley Marieth, Navarro-Rangel José Giovanni, Lara-Blanco Yair, Rodríguez-Uribe Genaro, Chavez-Méndez José Román

Abstract excerpt

BACKGROUND AND OBJECTIVE: Efavirenz is associated with frequent adverse effects, mainly hepatotoxicity and central nervous system disturbances. The cytochrome P450 enzyme CYP2B6 plays a key role in efavirenz metabolism and is strongly linked to these toxicities. This study aimed to evaluate the effect of the CYP2B6 c.516 G>T polymorphism on efavirenz plasma concentrations by comparing individuals with GG, GT, and...

Read the complete abstract on PubMed

Topics

Humans
Benzoxazines
Cytochrome P-450 CYP2B6
Cyclopropanes
Alkynes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HIV Infections

Tuberculosis

Anti-HIV Agents

Polymorphism, Single Nucleotide

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42337190
DOI: 10.1007/s13318-026-01017-x
PMCID: PMC13558313

Genes

CYP2B6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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