Article
Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 May 2005
Rodriguez-Novoa Sonia, Barreiro Pablo, Rendón Ana, Jiménez-Nacher Inmaculada, González-Lahoz Juan, Soriano Vincent
Abstract excerpt
We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus-positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of...
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