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Article

TiMEx: a waiting time model for mutually exclusive cancer alterations.

Bioinformatics (Oxford, England) - 1 Apr 2016

Constantinescu Simona, Szczurek Ewa, Mohammadi Pejman, Rahnenführer Jörg, Beerenwinkel Niko

Abstract excerpt

MOTIVATION: Despite recent technological advances in genomic sciences, our understanding of cancer progression and its driving genetic alterations remains incomplete. RESULTS: We introduce TiMEx, a generative probabilistic model for detecting patterns of various degrees of mutual exclusivity across genetic alterations, which can indicate pathways involved in cancer progression. TiMEx explicitly accounts for the...

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PMID: 26163509
DOI: 10.1093/bioinformatics/btv400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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