Article
Haplotypes of aldosterone synthase (CYP11B2) gene in the general population of Japan: the Ohasama study.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Nov 2001
Matsubara M, Omori F, Fujita S, Metoki H, Kikuya M, Fujiwara T, Araki T, Imai Y
Abstract excerpt
Since the identification of a chimeric aldosterone synthase which induces mendelian hypertension, polymorphisms in aldosterone synthase (CYP11B2) has been one of major targets for molecular analyses in association with hypertension. To date, four polymorphic variants of CYP11B2, -344T/C at promoter region, a gene conversion in intron 2, 2713A/G (in exon 3) which converts from Lys to Arg at codon 173 (K173R), and...
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