Article
Prediction of NK Cell Licensing Level in Selection of Hematopoietic Stem Cell Donor, Initial Results.
Archivum immunologiae et therapiae experimentalis - 1 Dec 2016
Rogatko-Koroś Marta, Mika-Witkowska Renata, Bogunia-Kubik Katarzyna, Wysoczańska Barbara, Jaskuła Emilia, Kościńska Katarzyna, Nestorowicz Klaudia, Dziopa Joanna, Szlendak Urszula, Gwozdowicz Sławomir, Graczyk-Pol Elżbieta, Lange Andrzej, Nowak Jacek
Abstract excerpt
Natural killer (NK) cell licensing status depends on clonal expression of inhibitory killer cell immunoglobulin-like receptors (iKIR) and short term HLA environment. Licensed NK cells are more efficient in tumor killing than unlicensed NK cells. Cognate KIR-HLA pairs in hematopoietic stem cell transplant (HSCT) donor and recipient are decisive for the possible change in the NK cell licensing status after HSCT. We...
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