Article
MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.
Breast cancer research : BCR - 8 Dec 2016
Young Adelaide I J, Law Andrew M K, Castillo Lesley, Chong Sabrina, Cullen Hayley D, Koehler Martin, Herzog Sebastian, Brummer Tilman, Lee Erinna F, Fairlie Walter D, Lucas Morghan C, Herrmann David, Allam Amr, Timpson Paul, Watkins D Neil, Millar Ewan K A, O'Toole Sandra A, Gallego-Ortega David, Ormandy Christopher J, Oakes Samantha R
Abstract excerpt
BACKGROUND: Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell survival and chemo-resistance in a wide range of malignancies, and thus its inhibition may prove to be therapeutically useful. METHODS: To examine whether targeting MCL-1 may provide an effective treatment for breast cancer, we constructed...
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