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Mcl-1 inhibitors: a patent review

17 Oct 2016

Abstract excerpt

INTRODUCTION: The myeloid cell leukemia-1 (MCL-1) protein is one of the key anti-apoptotic members of the B-cell lymphoma-2 (BCL-2) protein family. Over-expression of MCL-1 has been closely related to tumor progression as well as to resistance, not only to traditional chemotherapies but also to targeted therapeutics including BCL-2 inhibitors such as ABT-263. Therefore, there has been extensive research and...

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PMID: 27744724
DOI: 10.1080/13543776.2017.1249848

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