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Article

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Fong Sylvia, Itahana Yoko, Sumida Tomoki, Singh Jarnail, Coppe Jean-Philippe, Liu Yong, Richards Peter C, Bennington James L, Lee Nancy M, Debs Robert J, Desprez Pierre-Yves

Abstract excerpt

Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix. In addition, Id-1 is aberrantly over-expressed in aggressive and metastatic breast cancer cells, as well as in human breast tumor biopsies from infiltrating carcinomas, suggesting Id-1 might be an important regulator of breast cancer progression. We...

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Identifiers

PMID: 14578451
DOI: 10.1073/pnas.2230238100
PMCID: PMC263850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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