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Article

MCL-1 is a clinically targetable vulnerability in breast cancer

29 Mar 2022

Abstract excerpt

Pro-survival members of the BCL-2 family, including MCL-1, are emerging as important proteins during the development and therapeutic response of solid tumors. Notably, high levels of MCL-1 occur in breast cancer, where functional dependency has been demonstrated using cell lines and mouse models. The utility of restoring apoptosis in cancer cells through inhibition of pro-survival BCL-2 proteins has been realized...

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PMID: 35349392
DOI: 10.1080/15384101.2022.2054096

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