Article
An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.
Genome biology - 1 Jan 2013
Daxinger Lucia, Harten Sarah K, Oey Harald, Epp Trevor, Isbel Luke, Huang Edward, Whitelaw Nadia, Apedaile Anwyn, Sorolla Anabel, Yong Joan, Bharti Vandhana, Sutton Joanne, Ashe Alyson, Pang Zhenyi, Wallace Nathan, Gerhardt Daniel J, Blewitt Marnie E, Jeddeloh Jeffrey A, Whitelaw Emma
Abstract excerpt
BACKGROUND: We have used a sensitized ENU mutagenesis screen to produce mouse lines that carry mutations in genes required for epigenetic regulation. We call these lines Modifiers of murine metastable epialleles (Mommes). RESULTS: We report a basic molecular and phenotypic characterization for twenty of the Momme mouse lines, and in each case we also identify the causative mutation. Three of the lines carry a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.