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Article

Concordance between somatic copy number loss and down-regulated expression: A pan-cancer study of cancer predisposition genes.

Scientific reports - 8 Dec 2016

Wei Ran, Zhao Ming, Zheng Chun-Hou, Zhao Min, Xia Junfeng

Abstract excerpt

Cancer predisposition genes (CPGs) are a class of cancer genes in which germline variants lead to increased risk of cancer. Research has revealed that copy number variation (CNV) may be linked to cancer susceptibility in CPGs. In this pan-cancer analysis, we explored the relationship between somatic CNV and gene expression changes in CPGs. Based on curated 827 human CPGs from literature, we firstly identified 729...

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Topics

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Share to Databases, Genetic
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 27929028
DOI: 10.1038/srep37358
PMCID: PMC5144096

Genes

MCPH1
MINPP1
MTAP
PTEN
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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