Article
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
Nature communications - 15 Jan 2018
Teater Matt, Dominguez Pilar M, Redmond David, Chen Zhengming, Ennishi Daisuke, Scott David W, Cimmino Luisa, Ghione Paola, Chaudhuri Jayanta, Gascoyne Randy D, Aifantis Iannis, Inghirami Giorgio, Elemento Olivier, Melnick Ari, Shaknovich Rita
Abstract excerpt
Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that mediates affinity maturation and facilitates DNA demethylation in germinal center (GC) B cells, is required for DLBCL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.