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Article

Combined Kdm6a and Trp53 Deficiency Drives the Development of Squamous Cell Skin Cancer in Mice.

The Journal of investigative dermatology - 1 Feb 2023

Shea Lauren K, Akhave Neal S, Sutton Leslie A, Compton Leigh A, York Conner, Ramakrishnan Sai Mukund, Miller Christopher A, Wartman Lukas D, Chen David Y

Abstract excerpt

Cutaneous squamous cell carcinoma (cSCC) has among the highest mutation burdens of all cancers, reflecting its pathogenic association with the mutagenic effects of UV light exposure. Although mutations in cancer-relevant genes such as TP53 and NOTCH1 are common in cSCC, they are also tolerated in normal skin and suggest that other events are required for transformation; it is not yet clear whether epigenetic...

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Identifiers

PMID: 36055401
DOI: 10.1016/j.jid.2022.08.037
PMCID: PMC10334302

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