Article
Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
The Journal of biological chemistry - 1 Jan 2000
Munier Claire C, De Maria Leonardo, Edman Karl, Gunnarsson Anders, Longo Marianna, MacKintosh Carol, Patel Saleha, Snijder Arjan, Wissler Lisa, Brunsveld Luc, Ottmann Christian, Perry Matthew W D
Abstract excerpt
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that plays a central role in inflammation. The GR activity is also modulated via protein-protein interactions, including binding of 14-3-3 proteins induced by GR phosphorylation. However, the specific phosphorylation sites on the GR that trigger these interactions and their functional consequences are less clear. Hence, we sought to...
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