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Article

Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Feb 2007

Ramos Alberto, Ho Wai Chi, Forte Stephanie, Dickson Kathleen, Boutilier Jacqueline, Favell Kristy, Barker Philip A

Abstract excerpt

Injury-induced expression of the p75 neurotrophin receptor (p75NTR) in the CNS facilitates neuronal apoptosis and prevents neuronal regrowth, but the mechanisms regulating p75NTR expression are poorly characterized. In this study, we showed that hypo-osmolarity induces p75NTR expression in primary neurons, and, using a comparative genomics approach, we identified conserved elements in the 25 kb upstream sequences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17287525
DOI: 10.1523/JNEUROSCI.4806-06.2007
PMCID: PMC6673569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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