Article
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.
Human molecular genetics - 1 Dec 2010
Murphy Amy, Chu Jen-Hwa, Xu Mousheng, Carey Vincent J, Lazarus Ross, Liu Andy, Szefler Stanley J, Strunk Robert, Demuth Karen, Castro Mario, Hansel Nadia N, Diette Gregory B, Vonakis Becky M, Adkinson N Franklin, Klanderman Barbara J, Senter-Sylvia Jody, Ziniti John, Lange Christoph, Pastinen Tomi, Raby Benjamin A
Abstract excerpt
Genome-wide association studies of human gene expression promise to identify functional regulatory genetic variation that contributes to phenotypic diversity. However, it is unclear how useful this approach will be for the identification of disease-susceptibility variants. We generated gene expression profiles for 22 184 mRNA transcripts using RNA derived from peripheral blood CD4+ lymphocytes, and genome-wide...
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